Table 1.

List of all drugs approved for COVID-19, their liver contraindications, risk level of DILI and its most common pattern.

Drug	Liver Contraindications	Risk Level of DILI	DILI Pattern
systemic corticosteroids	Generic caution in liver failure	+	hepatocellular or mixed
tocilizumab	ALT > 5 times URL	++	hepatocellular
sarilumab	ALT > 1.5 times URL	++	hepatocellular
anakinra	Not recommended in severe liver failure (Child-Pugh C)	+	hepatocellular
baricitinib, tofacitinib, imatinib	Not recommended in severe liver failure (Child-Pugh C)	+	hepatocellular
remdesivir	ALT > 5 times URL	++	hepatocellular
low-molecular-weight heparins	Generic caution in liver failure	+	hepatocellular
NSAIDs	Contraindicated in severe liver failure (Child-Pugh C), caution in mild or moderate liver failure (indication to use low dosage)	++	hepatocellular
paracetamol	Contraindicated in severe liver failure (Child-Pugh C), caution in mild or moderate liver failure (indication to use low dosage)	++++	hepatocellular
antibiotics amoxicillin-clavulanate trimethoprim/sulfamethoxazole azitromicin		+++ ++ ++	cholestatic cholestatic mixed