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. 2022 Feb 25;17(2):e0264386. doi: 10.1371/journal.pone.0264386

Fig 4. Influence of daily administration of suvorexant or mirtazapine on the duration of arousal and sleep in PSNL.

Fig 4

The mean durations of wakefulness, non-REM sleep, and REM sleep in both suvorexant (a) and mirtazapine (b) experiments, were calculated every 6 h. Data are expressed as means ± SEMs (sham-vehicle, n = 5–6; PSNL-vehicle, n = 5; PSNL-suvorexant, n = 6; PSNL-mirtazapine, n = 5). *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001 compared between each sham-vehicle and PSNL-vehicle group, and +P < 0.05, ++P < 0.01, +++P < 0.001, and ++++P < 0.0001 compared between each PSNL-vehicle and PSNL-drug (suvorexant or mirtazapine) group by two-way ANOVA with Bonferroni post-test. Abbreviations: ANOVA, analysis of variance; PSNL, partial sciatic nerve ligation; REM, rapid eye movement; SEM, standard error of the mean; ZT, Zeitgeber time.