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. 2022 Feb 25;17(2):e0263680. doi: 10.1371/journal.pone.0263680

Table 3. Unadjusted and multivariable-adjusted Cox’s proportional hazard regressions for the primary outcome 30-day mortality.

Parameter Unadjusted Multivariable-adjusted
HR 95% CI p-value HR 95% CI p-value
Period 5 1.4–18 0.013 8.7 2.15–35 0.002
Period * - - - 5.5 1.44–21 0.01
Charlson 1.11 0.93–1.33 0.217 1.04 0.82–1.32 0.69
Charlson * 1.09 0.92–1.28 0.312 0.96 0.79–1.16 0.68
Sex (h) 3.44 1.19–9.9 0.01 1.13 0.98–10 0.052
Sex (h) * - - - 3.5 1.2–10 0.022
Age 1.03 0.96–1.09 1 - - -
ADL 0.69 0.53–0.9 0.006 0.6 0.45–0.82 0.001
ADL * 0.68 0.52–0.88 0.004 0.5 0.37–0.87 0.009
IADL 0.78 0.53–1.15 0.4 - - -
IADL * 0.79 0.55–1.12 0.18 1.9 0.69–1.91 0.57
COVID infection 2.5 0.7–9 0.15 0.44 0.1–1.9 0.28
COVID infection * - - - 0.68 0.16–2.90 0.63
Delay 0.89 0.65–1.24 0.52 - - -
Diagnosis£ 1.4 0.47–4.1 0.54 - - -

Parameters with a p-value less than 0.2 in the unadjusted analysis were included in the multivariable Cox’s PH regression. £ diagnosis either AO31A or AO31B fracture.

* results after Multivariate Imputation by Chained Equation (MICE) approach.