Table 2. Associations between relative microRNA expressions and markers of inflammation, endothelial function and vascular relaxation.
| miRNA-146a-5p* | miRNA-155-5p* | |||||
|---|---|---|---|---|---|---|
| N | std β (SE) | p | n | std β (SE) | p | |
| Unadjusted | ||||||
| Circulating inflammatory markers | ||||||
| CRP | 57 | 0.34(0.13) | 0.01 | 54 | 0.28(0.13) | 0.03 |
| TNF- α | 54 | 0.31(0.12) | 0.01 | 52 | 0.14(0.13) | 0.26 |
| IL-6 | 55 | 0.23(0.13) | 0.09 | 52 | 0.04(0.13) | 0.77 |
| Circulating endothelial function markers | ||||||
| VCAM-1 | 35 | 0.17(0.15) | 0.26 | 31 | 0.03(0.13)) | 0.81 |
| PTX-3 | 35 | 0.35(0.15) | 0.03 | 31 | 0.03(0.17) | 0.87 |
| Vascular relaxation markers | ||||||
| Mesenteric artery ACh EC50 | 41 | 0.35(0.17) | 0.04 | 41 | 0.16(0.17) | 0.35 |
| Mesenteric artery ACh Emax | 41 | -0.23(0.18) | 0.20 | 41 | -0.43(0.16) | 0.009 |
| Multivariate adjusted # | ||||||
| Circulating inflammatory markers | ||||||
| CRP | 57 | 0.36(0.13) | 0.009 | 54 | 0.39(0.12) | 0.003 |
| TNF- α | 54 | 0.33(0.13) | 0.01 | 52 | 0.29(0.13) | 0.03 |
| IL-6 | 55 | 0.25(0.14) | 0.08 | 52 | 0.16(0.13) | 0.19 |
| Circulating endothelial function markers | ||||||
| VCAM-1 | 35 | 0.16(0.17) | 0.34 | 31 | 0.11(0.15) | 0.47 |
| PTX-3 | 35 | 0.48(0.16) | 0.007 | 31 | 0.16(0.17) | 0.36 |
| Vascular relaxation markers | ||||||
| Mesenteric artery ACh EC50 | 41 | 0.38(0.18) | 0.04 | 41 | 0.18(0.17) | 0.28 |
| Mesenteric artery ACh Emax | 41 | -0.25(0.19) | 0.20 | 41 | -0.43(0.16) | 0.009 |
* Logarithmically transformed variables.
# adjusted for body mass and blood pressure. CRP: C reactive protein; TNF-α: Tumour necrosis factor alpha; IL-6: Interleukin-6; VCAM-1: Vascular adhesion molecule-1; PTX-3: Pentraxin-3; ACh: Acetylcholine.