Table 1.
Distribution of KilA-N, Bro-N and associated conserved domains in viral and cellular proteomes
| Organism | Host, if phage or virus | Domain architectures |
| NCLDVs, baculoviruses | Eukaryotes | KilA-N solo (AMV, FPV) |
| KilA-N + Bro-C (AMV, CIV, FPV) | ||
| KilA-N + T5ORF172 (CIV) | ||
| KilA-N + RING finger (chordopoxviruses); ectromelia p28 [12] | ||
| KilA-N + CCCH + RING finger (FPV) | ||
| Bro-N solo (MSV, AMV, HzNV, LdNV, XnGV) | ||
| Bro-N + Bro-N (CnBV, CpGV, PxGV) | ||
| Bro-N + T5ORF172 (CIV, MSV, ESV, baculoviruses) | ||
| Bro-N + Bro-C (AMV, baculoviruses); BroA, BroD of BmNV [10] | ||
| Bro-N + Bro-N + Bro-C (HaNV) | ||
| Bro-N + VSR nuclease (MSV, CIV) | ||
| Bro-N + Bro-N (CnBV, CpGV) | ||
| Bro-N + Bro-C (AMV, baculoviruses) | ||
| MSV199 solo (MSV) | ||
| MSV199 + T5ORF172 (AMV, MSV, CIV) | ||
| MSV199 + UVRC (CIV) | ||
| MSV199 + Bro-C (CIV) | ||
| Bro-C solo (CIV, DpAV4, AcNV, BmNV, EpNV, LdNV, LsNV, MbNV, OpNV) | ||
| T5ORF172 solo (CIV, LdNV) | ||
| Proteobacteria | - | KilA-N solo (N. meningitidis, X. fastidiosa) |
| Bro-N solo (N. meningitidis, X. fastidiosa, Pseudomonas aeruginosa) | ||
| Bro-N (2/3 copies) + XF1559 (X. fastidiosa) | ||
| XF0704 + Bro-N (X. fastidiosa) | ||
| Bro-N + P22AR-C (Escherichia coli) | ||
| KilA-C solo (E. coli) | ||
| φ31-ORF238N + P22AR-C (Haemophilus influenzae) | ||
| φ31-ORF238N + wHTH (N. meningitidis) | ||
| XF0704 solo (X. fastidiosa) | ||
| XF1559 solo (X. fastidiosa) | ||
| RHA solo (Pasteurella multocida) | ||
| RHA + D3ORF11-C (H. influenzae) | ||
| RHA + ASH (Shigella flexneri) | ||
| D3ORF11-C + P22AR-N (E. coli) | ||
| bIL285ORF6-N solo (E. coli) | ||
| ASH solo (E. coli, S. flexneri) | ||
| T5ORF172 solo (N. meningitidis) | ||
| Low-GC Gram-positive bacteria/ Firmicutes | - | Bro-N solo (Streptococcus pyogenes) |
| Bro-N + HTH (S. pyogenes) | ||
| Bro-N + KilA-C (S. pyogenes, Staphylococcus aureus) | ||
| RHA solo (Streptococcuspneumoniae) | ||
| φ31-ORF238N + KilA-C (S. pyogenes, S. aureus) | ||
| φ31-ORF238N + φSLT-orf81a (Clostridium acetobutylicum) | ||
| T5ORF172 solo (Bacillus subtilis) | ||
| KilA-C solo (Lactococcus lactis) | ||
| High-GC Gram-positive bacteria | - | Bro-N solo (Streptomyces coelicolor) |
| Phages BP7888, BP933W, BPHK97, BPN15, BPHK620, BPHK022, BPφ-R73 BPP22, BPH-19B, BPP1, BPP4, BPP27, BPφ80, BPT5, BPVT2-Sa | Escherichia coli | Bro-N solo (BPN15) |
| KilA-N + KilA-C; phage P1 - KilA [14] | ||
| KilA-N + D3ORF11-C (BPHK620) | ||
| KilA-N + p63C (BP933W, BPHK97) | ||
| RHA solo (BPφ80); BPP22 ORF 201 [47] | ||
| RHA + KilA-C (BPHK022, BP933W, BPP1, BPH-19B, BPHK97, BPHK620, | ||
| BPVT2-Sa); Reduced on IHF- (ROI) [48] | ||
| KilA-C solo; bacteriophage P1 antirepressor Ant1/Ant2 [49] | ||
| φ31-ORF238N + P22AR-C (BP933W, BPVT2-Sa) | ||
| D3ORF11-C + P22AR-N (BP933W, BP7888) | ||
| ASH solo (BPP4, BPφ-R73, BPN15) | ||
| bIL285ORF6-N + P22AR-C (BPVT2-Sa) | ||
| T5ORF172 solo (BPT5, BPP27) | ||
| Phage P22 | Salmonella typhimurium | P22AR-N + Bro-N + P22AR-C; BPP22 antirepressor [33,34] |
| RHA + D3ORF11-C [46] | ||
| Phage APSE-1 | Buchnera aphidicola | RHA (solo) |
| Bro-N (solo) | ||
| Phage D3 | Pseudomonas aeruginosa | KilA-N + D3ORF11-C |
| BPφPV83, BPφETA, BPφSLT | Staphylococcus aureus | Bro-N + KilA-C (BPφPV83) |
| φ31-ORF238N + KilA-C (BPφETA) | ||
| φSLT-ORF81a solo (BPφSLT) | ||
| RHA solo (BPφSLT) | ||
| BPbIL285, BPbIL286, BPbIL311, BPbIL309, BPpi3, BPφ31.1, BPTP901-1, BPR1T, BPBK5-T, BPLL-H, BPTuc2009 | Lactococcus lactis | Bro-N + KilA-C (BPR1T, BPBK5-T, BPLL-H, BPbIL309) |
| KilA-C solo (BPR1T) | ||
| RHA solo (BpbIL310, BPbIL311) | ||
| φ31-ORF238N + bIL285ORF6-C (BPpi3, BPTuc2009, BPbIL286, BPφ31.1) | ||
| bIL285ORF6-N + bIL285ORF6-C (BPbIL285, BPTP901-1) | ||
| LcBPA2 | Lactobacillus casei | Bro-N solo |
| BPTP-J34, BPSfi21 | Streptococcus thermophilus | φ31-ORF238N + KilA-C |
| BPA118 | Listeria monocytogenes | φ31-ORF238N + KilA-C |
| BPSpβc2 | Bacillus subtilis | RHA + KilA-C |
| BPMx8 (Myxococcal phage) | Myxococcus xanthus | Bro-N + p63C |