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. 2022 Feb 22;37(1):792–816. doi: 10.1080/14756366.2022.2041627

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Scheme 3. — Synthesis of 7,4’-O-modified apigenin derivatives 10a–10v. Reagents and conditions: (i) Br(CH₂)_nBr (2a–2d), K₂CO₃, CH₃CN, 65 °C, 10–15 h; (ii) R₁R₂NH (4a–4j), K₂CO₃, CH₃CN, 65 °C 8–12 h.