Table 6.
Compound | Propidium iodide displacement from AChE PAS (% inhibition)a |
|
---|---|---|
10 μM | 50 μM | |
5f | 25.7 ± 1.9 | 36.9 ± 3.5 |
7k | 23.1 ± 1.2 | 34.3 ± 2.1 |
Donepezil | 20.9 ± 2.7 | 33.4 ± 2.6 |
aPropidium iodide displacement assay was performed on AChE to test the ability of compounds 5f and 7k to displace propidium with reference to the donepezil at 10 and 50 μM. Data are presented as the mean ± SEM of three independent experiments.