Table 7.

Effects on self-induced/Cu²⁺-induced Aβ_1–42 aggregation by compounds 5f, 7k and curcumin.

Compound	Inhibition of Aβ1–42 aggregationa		Inhibition of huAChE-induced Aβ1–40 aggregation (%)d
	Self-induced (%)b	Cu2+-induced (%)c
5f	62.1 ± 0.38	73.5 ± 0.25	51.7 ± 0.75
7k	43.8 ± 0.51	68.7 ± 0.46	43.4 ± 0.43
Donepezil	N.T.e	N.T.e	28.2 ± 0.29
Curcumin	45.9 ± 0.67	50.6 ± 0.33	N.T.e

^aThe inhibition effects of Aβ_1–42 aggregation was tested using thioflavin-T fluorescence assay, data are expressed as the mean ± SEM by three independent experiments. ^bInhibition of self-induced Aβ_1–42 aggregation, both the concentration of tested compounds and Aβ_1–42 were 25 μM. ^cInhibition of Cu²⁺-induced Aβ_1–42 aggregation, both the tested compounds and Aβ_1–42 were 25 μM. ^d The inhibition huAChE-induced Aβ_1–40 aggregation was tested using ThT fluorescence assay, the concentration of tested inhibitor and Aβ_1–40 was 100 and 230 μM, respectively, whereas the Aβ_1–40/AChE ratio was equal to 100/1. Data are expressed as the mean ± SEM through three independent experiments. ^e N.T. = not tested.