Table 8.

The predictive permeation of compounds 5f and 7k by PAMPA-BBB assay.

Compounda	Pe (×10−6 cm/s)b	Prediction
Testosterone	17.8 ± 0.93	CNS+
Verapamil	16.3 ± 0.82	CNS+
Clonidine	5.8 ± 0.21	CNS+
Norfloxacin	0.13 ± 0.01	CNS-
5f	6.9 ± 0.36	CNS+
7k	11.7 ± 0.54	CNS+

^aCompounds 5f and 7k were dissolved in DMSO at 5 mg/mL and diluted with PBS/EtOH (70:30). The final concentration of compounds was 100 μg/mL. ^bValues are expressed as the mean ± SD of three independent experiments.