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. 2022 Feb 18;2022:2203615. doi: 10.1155/2022/2203615

Figure 3.

Figure 3

The prognostic value of DEFB1 in OSCC. (a) Survival heat map of hazard ratio (HR) shows the prognostic impacts of the DEFB1 gene on the overall survival (OS) outcomes of multiple cancer types according to the GEPIA2 database. The bounding boxes represented the significant (p < 0.05) unfavorable (red) and favorable (blue) results, respectively. (b) Survival heat map of hazard ratio (HR) shows the prognostic impacts of the DEFB1 gene on the disease-free survival (DFS) outcomes of multiple cancer types according to the GEPIA2 database. (c) The prognostic values of DEFB1 in OSCC from the aspect of three types of prognostic parameters (i.e., overall survival, disease-specific survival, and progress-free interval). (d) The subgroup survival analysis showing the association between DEFB1 mRNA overexpression and overall survival outcome of OSCC in specific subgroups dividing by the clinical characteristics, for example, higher T stage T3 and T4; M stage M0; gender: female; age: >60; smoker: yes; radiation therapy: no; primary therapy outcome: PR and CR; lymphovascular invasion: no; and lymph node dissection: yes. (e) The forest plots showing the univariate and multivariate regression analysis results of DEFB1 and clinicopathologic parameters with overall survival (OS) in OSCC patients.