Table 2.
The clinical characteristics of the TCGA-OSCC patients depending on the expression level of DEFB1 gene.
| Characteristic | Levels | Low expression of DEFB1 | High expression of DEFB1 | p |
|---|---|---|---|---|
| n | 164 | 165 | ||
| T stage, n (%) | T1 | 10 (3.1%) | 8 (2.5%) | 0.964 |
| T2 | 53 (16.6%) | 52 (16.3%) | ||
| T3 | 40 (12.5%) | 42 (13.2%) | ||
| T4 | 57 (17.9%) | 57 (17.9%) | ||
| N stage, n (%) | N0 | 78 (24.8%) | 90 (28.6%) | 0.415 |
| N1 | 31 (9.8%) | 25 (7.9%) | ||
| N2 | 49 (15.6%) | 39 (12.4%) | ||
| N3 | 1 (0.3%) | 2 (0.6%) | ||
| M stage, n (%) | M0 | 156 (50%) | 154 (49.4%) | 1.000 |
| M1 | 1 (0.3%) | 1 (0.3%) | ||
| Clinical stage, n (%) | Stage I | 6 (1.9%) | 5 (1.6%) | 0.887 |
| Stage II | 37 (11.6%) | 42 (13.2%) | ||
| Stage III | 32 (10%) | 33 (10.3%) | ||
| Stage IV | 85 (26.6%) | 79 (24.8%) | ||
| Radiation therapy, n (%) | No | 60 (20.3%) | 56 (19%) | 0.828 |
| Yes | 89 (30.2%) | 90 (30.5%) | ||
| Primary therapy outcome, n (%) | PD | 16 (5.8%) | 19 (6.8%) | 0.312 |
| SD | 3 (1.1%) | 1 (0.4%) | ||
| PR | 3 (1.1%) | 0 (0%) | ||
| CR | 121 (43.5%) | 115 (41.4%) | ||
| Gender, n (%) | Female | 49 (14.9%) | 53 (16.1%) | 0.748 |
| Male | 115 (35%) | 112 (34%) | ||
| Race, n (%) | Asian | 3 (0.9%) | 6 (1.9%) | 0.684 |
| Black or African American | 11 (3.5%) | 10 (3.1%) | ||
| White | 144 (45.3%) | 144 (45.3%) | ||
| Age, n (%) | ≤60 | 81 (24.7%) | 74 (22.6%) | 0.442 |
| >60 | 82 (25%) | 91 (27.7%) | ||
| Histologic grade, n (%) | G1 | 17 (5.3%) | 35 (10.9%) | 0.043 |
| G2 | 105 (32.7%) | 95 (29.6%) | ||
| G3 | 36 (11.2%) | 31 (9.7%) | ||
| G4 | 1 (0.3%) | 1 (0.3%) | ||
| Anatomic neoplasm subdivision, n (%) | Alveolar ridge | 6 (1.8%) | 12 (3.6%) | 0.250 |
| Base of tongue | 12 (3.6%) | 11 (3.3%) | ||
| Buccal mucosa | 14 (4.3%) | 8 (2.4%) | ||
| Floor of mouth | 33 (10%) | 28 (8.5%) | ||
| Hard palate | 1 (0.3%) | 6 (1.8%) | ||
| Oral cavity | 37 (11.2%) | 35 (10.6%) | ||
| Oral tongue | 61 (18.5%) | 65 (19.8%) | ||
| Smoker, n (%) | No | 43 (13.3%) | 44 (13.6%) | 1.000 |
| Yes | 118 (36.5%) | 118 (36.5%) | ||
| Alcohol history, n (%) | No | 41 (12.8%) | 64 (19.9%) | 0.012 |
| Yes | 118 (36.8%) | 98 (30.5%) | ||
| Lymphovascular invasion, n (%) | No | 81 (33.9%) | 83 (34.7%) | 0.965 |
| Yes | 38 (15.9%) | 37 (15.5%) | ||
| Lymph node neck dissection, n (%) | No | 28 (8.6%) | 17 (5.2%) | 0.104 |
| Yes | 135 (41.3%) | 147 (45%) | ||
| OS event, n (%) | Alive | 82 (24.9%) | 97 (29.5%) | 0.136 |
| Dead | 82 (24.9%) | 68 (20.7%) | ||
| DSS event, n (%) | Alive | 105 (33.7%) | 114 (36.5%) | 0.414 |
| Dead | 50 (16%) | 43 (13.8%) | ||
| PFI event, n (%) | Alive | 90 (27.4%) | 104 (31.6%) | 0.164 |
| Dead | 74 (22.5%) | 61 (18.5%) | ||
| Age, median (IQR) | 61 (52, 71) | 62 (55, 69) | 0.524 |