Table 1.
In vitro antifungal susceptibility test results and presence of mutation detected on CYP51A gene sequence of the nine isolates analyzed.
Isolate | Days after first hospitalization | Clinical specimen | CLSI MIC (μg/mL) |
CYP51A mutation | |||||
---|---|---|---|---|---|---|---|---|---|
MCFG | CPFG | AMPH-B | ITC | VRC | POS | ||||
LIF 3297 | +12 | Renal abscess | 0.03 | 0.25 | 1 | 0.5 | 2 | 0.25 | None |
LIF 3309 | +43 | Renal abscess | 0.015 | 0.12 | 2 | 0.5 | 2 | 0.25 | None |
LIF 3365 | +114 | Renal abscess | 0.015 | 0.5 | 2 | 0.5 | 4 | 0.5 | None |
LIF 3492 | +426 | Prostate | 0.015 | 0.25 | 2 | 0.5 | 2 | 0.25 | None |
LIF 3519 | +427 | Prostate | 0.015 | 0.12 | 2 | 0.5 | 1 | 0.25 | None |
LIF 3495 | +456 | Prostate | 0.015 | 0.25 | 1 | 0.5 | 1 | 0.25 | None |
LIF 3545 | +489 | Prostate | 0.015 | 0.12 | 1 | 1 | 4 | 0.25 | None |
LIF 3546 | +489 | Renal capsule | 0.015 | 0.12 | 2 | 2 | >8 | 0.5 | G448S |
LIF 3608 | +740 | Pleural fluid | 0.015 | 0.25 | 2 | 2 | >8 | 1 | G448S |
MICs were determined using CLSI method M38-A2. MCFG, micafungin; CPFG, caspofungin; AMPH-B, amphotericin B; ITC, itraconazole; VRC, voriconazole; POS, posaconazole.