Table 3.
Change in variables in obese with NAFLD children treated with GH vs control group for 3 months
| Variable | rhGH group (n = 22) |
control group (n = 22) |
p value |
|---|---|---|---|
| BMI SDS | 2.37 ± 0.69 | 2.66 ± 0.54 | 0.138 |
| IGF-1(ng/ml) | 473.36 ± 159.12 | 355.86 ± 126.98 | 0.01* |
| CRP(mg/L) | 1.24 ± 0.80 | 2.07 ± 1.14 | 0.008* |
| ALT(U/L) | 18.25(13.50,27.75) | 21.00(16.75, 42.25) | 0.113▲ |
| AST(U/L) | 21.50(19.88,28.75) | 23.00(20.00, 30.50) | 0.430▲ |
| GGT(U/L) | 14.00(12.75,17.75) | 24.00(20.00, 33.25) | < 0.001*▲ |
| TC(mmol/L) | 3.99 ± 0.59 | 4.15 ± 0.76 | 0.432 |
| HDL-C (mmol/L) | 1.41 ± 0.30 | 1.12 ± 0.20 | 0.001* |
| LDL-C (mmol/L) | 2.17 ± 0.42 | 2.49 ± 0.53 | 0.033* |
| TG(mmol/L) | 0.90(0.71, 1.52) | 1.05(0.82, 1.38) | 0.578# |
| UA(μmol/L) | 423.96 ± 97.51 | 376.64 ± 78.65 | 0.084 |
| Insulin(uIU/mL) | 31.16(21.28,36.75) | 17.04(14.43, 28.46) | 0.086# |
| FBG(mmol/L) | 5.34 ± 0.31 | 5.25 ± 0.40 | 0.393 |
| HOMA-IR | 7.34(5.16, 8.76) | 3.99(3.02, 6.94) | 0.078# |
| HbA1c (%) | 5.62 ± 0.35 | 5.62 ± 0.30 | 1# |
# p value reported for log transformed values, but values in the table represent as the median (interquartile range) ▲Mann–Whitney U test
* p < 0.05
Abbreviations: BMI SDS Body mass index standard deviation scores, IGF-1 Insulin-like growth factor 1, CRP C reactive protein, ALT Alanine aminotransferase, AST Aspartate aminotransferase, GGT Gamma-glutamyl transferase, GH Growth hormone, TC Total cholesterol, HDL-C High density lipoprotein cholesterol, LDL-C Low density lipoprotein cholesterol, TG Triglycerides, UA Uric acid, FBG Fasting blood glucose, HOMA-IR Homeostasis model assessment of IR, HbA1c Glycosylated haemoglobin