TABLE 3.
Minimally and fully adjusted group differences in plasma choline and selected nutrients at 6-mo follow-up in young Malawian children enrolled in the Mazira Project egg intervention trial (n = 400)1
| Minimally adjusted2 | Fully adjusted3 | |||
|---|---|---|---|---|
| Estimate (95% CI)4 | P value | Estimate (95% CI)4 | P value | |
| Plasma choline | 0.15 (−0.03, 0.34) | 0.11 | 0.17 (−0.02, 0.35) | 0.08 |
| Plasma betaine | 0.07 (−0.09, 0.24) | 0.38 | 0.09 (−0.07, 0.26) | 0.28 |
| Plasma DMG5 | −0.01 (−0.07, 0.05) | 0.75 | −0.01 (−0.07, 0.05) | 0.66 |
| Plasma TMAO5 | 0.26 (0.10, 0.43) | 0.002 | 0.23 (0.07, 0.39) | 0.01 |
| Plasma DHA | −0.07 (−0.27, 0.12) | 0.45 | −0.05 (−0.24, 0.15) | 0.62 |
DMG, dimethylglycine; TMAO, trimethylamine N-oxide.
Adjusted for baseline plasma values.
Additionally adjusted for child age, sex, and birth order; maternal age, height, education, occupation, literacy, marital status, tribe, and religion; housing and asset index; animal ownership; food insecurity score; distance to water source; number of children aged <5 y in the household; village location (Lungwena compared with Malindi health center catchment areas); month of data collection; and time since last intake of food or drink. Covariates were included in the model if they were associated with plasma variable with P < 0.1.
Estimates are β coefficients representing the effect of egg intervention group assignment, in SD units. These estimates use relative intensity data, and cannot be directly translated to effect per absolute concentration (i.e., micromoles per liter).
Outcome variable was log transformed. Estimates represent the difference in the means of the log outcome; after exponentiation, this value can be interpreted as the ratio of the geometric means.