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. 2022 Feb 23;6(2):nzab150. doi: 10.1093/cdn/nzab150

TABLE 4.

Metabolites for which there was a statistically significant intervention effect with large-magnitude fold change after Malawian children consumed 1 egg/d for 6 mo (n = 400)1

Code Biochemical2 Superpathway Subpathway P value Fold change3
x40473_6 Hydantoin-5-propionate Amino acid Histidine metabolism 0.016 0.821
x57687_6 N,N,N-Trimethyl-5-aminovalerate Amino acid Lysine metabolism 0.003 1.21
x541_6 4-Hydroxyphenylacetate Amino acid Phenylalanine metabolism 0.028 1.23
x27672_6 3-Indoxyl sulfate Amino acid Tryptophan metabolism 0.015 1.30
x37092_6 γ-Glutamyl-2-aminobutyrate Peptide γ-Glutamyl amino acid 0.001 1.27
x48425_6 Phenylacetylcarnitine Peptide Acetylated peptides 0.006 1.35
x35126_6 Phenylacetylglutamine Peptide Acetylated peptides 0.003 1.30
x396_6 Glutarate (C5-DC) Lipid Fatty acid dicarboxylate 0.046 1.21
x54907_6 Hexanoylglutamine Lipid Fatty acid metabolism (acyl glutamine) 0.003 0.834
x40406_6 Trimethylamine N-oxide Lipid Phospholipid metabolism 0.004 1.25
x35625_6 1-Myristoyl-glycerol Lipid Monoacylglycerol 0.002 0.787
x32506_6 2-Linoleoyl-glycerol Lipid Monoacylglycerol 0.009 0.827
x54966_6 Diacylglycerol* Lipid Diacylglycerol 0.014 0.816
x57373_6 Palmitoyl-docosahexaenoyl-glycerol* Lipid Diacylglycerol 0.010 0.838
x37198_6 5α-Pregnan-3β,20α-diol disulfate Lipid Progestin steroids 0.000 1.33
x32425_6 Dehydroepiandrosterone sulfate (DHEA-S) Lipid Androgenic steroids 0.008 1.27
x38168_6 16α-Hydroxy DHEA 3-sulfate Lipid Androgenic steroids 0.019 1.19
x63731_6 Glycoursodeoxycholic acid 3-sulfate Lipid Secondary bile acid metabolism 0.009 1.38
x601_6 Dihydroorotate Nucleotide Pyrimidine metabolism, orotate containing 0.006 0.818
x15753_6 Hippurate Xenobiotics Benzoate metabolism 0.014 1.37
x62533_6 (2,4 or 2,5)-Dimethylphenol sulfate Xenobiotics Food component/plant 0.017 0.793
x48698_6 6-Hydroxyindole sulfate Xenobiotics Chemical 0.025 1.32
1

Metabolites with statistically significant P values (P < 0.05) from linear regression models adjusted for baseline measures of the outcome variables and child age and sex, and large-magnitude fold changes (log2 fold change >0.25), which were calculated as the ratio of geometric means. Biochemical compound codes, names, superpathways, and subpathways provided by Metabolon Inc.

2

An asterisk (*) indicates compounds that have not been officially confirmed based on a standard, but for which Metabolon Inc is confident in the identity.

3

Fold changes for which the intervention egg group had a higher mean are >1, and fold changes for which the control group had a higher mean are <1.