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. 2021 Dec 11;45(1):193–198. doi: 10.1007/s13402-021-00650-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — MMP12 expression in normal kidney and renal cell carcinoma (RCC). (A) Part of a heat map showing differential gene expression in conventional RCC (cRCC), papillary RCC (pRCC) and sarcomatous RCC (sRCC). The expression of MMP12, as well as that of ANLN and ADAM12, is upregulated in sRCC (red). None of the pRCCs, but 4 cRCCs without sarcomatous histology, exhibited a high MMP12 expression. (B) Immunohistochemistry of MMP12 expression. (a) Strong MMP12 expression in distal tubules (DT) of the adult kidney; proximal tubules (PT) are negative. (b) Lack of MMP12 expression in a cRCC. (c) Diffuse, weak MMP12expression in a cRCC with epithelial histology. (d) Strong MMP12 expression in a sRCC. (e) Strong cytoplasmic MMP12 expression in a rhabdoid cRCC. (f) Papillary growing epithelial cRCC displaying strong MMP12 expression in the basal regions of the tumour cells (arrows)