Table 2.
Multivariate analysis: expression of MMP12 protein is an independent prognostic factor indicating 2–3 times higher risk of cancer relapse (p ≤ 0.001; p ≤ 0.003)
| RR | 95.0% CI for Exp(B) | p-value | ||
|---|---|---|---|---|
| Lower | Upper | |||
| Sex | 1.015 | 0.690 | 1.492 | 0.941 |
| Size | 0.022 | |||
| Size < 7 cm | 1.807 | 0.931 | 3.506 | 0.080 |
| Size > 7 cm | 0.954 | 0.408 | 2.229 | 0.913 |
| T1 | 0.855 | |||
| T2 | 1.160 | 0.163 | 8.240 | 0.882 |
| T3 | 1.456 | 0.315 | 6.729 | 0.631 |
| G1 | 0.033 | |||
| G2 | 1.785 | 1.091 | 2.920 | 0.021 |
| G3 | 2.181 | 1.151 | 4.133 | 0.017 |
| Stage I | 0.032 | |||
| Stage II | 1.767 | 1.081 | 2.888 | 0.023 |
| Stage III | 2.218 | 1.173 | 4.194 | 0.014 |
| MMP12 negative | < 0.001 | |||
| MMP12 weak positive | 2.785 | 1.717 | 4.518 | < 0.001 |
| MMP12 strong positive | 2.391 | 1.344 | 4.254 | 0.003 |