Table 4.
Association between GAP score and CPI at enrollment and clinical outcomes
| Death | Lung transplant | Hospitalization | Death or lung transplant | Death, lung transplant, or hospitalization | |
|---|---|---|---|---|---|
| GAP score | |||||
| Overall association | |||||
| HR (95% CI) per 1-point increase | 1.44 (1.28, 1.62) | 0.99 (0.79, 1.22) | 1.00 (0.91, 1.10) | 1.23 (1.10, 1.38) | 1.08 (0.99, 1.18) |
| p-value | <0.001 | 0.89 | 0.99 | <0.001 | 0.073 |
| P-value for interaction between GAP score and presence of emphysema | 1.00 | – | 0.070 | 0.78 | 0.16 |
| HR (95% CI) per 1-point increase in patients with CPFE | – | – | 1.24 (0.97, 1.59) | – | – |
| HR (95% CI) per 1-point increase in patients with IPF alone | – | – | 0.98 (0.88, 1.08) | – | – |
| CPI | |||||
| Overall association | |||||
| HR (95% CI) per 5-point increase | 1.38 (1.26, 1.51) a | 1.39 (1.23, 1.57) a | 1.01 (0.95, 1.07) | 1.40 (1.29, 1.51) a | 1.18 (1.11, 1.26) a |
| p-value | < 0.001 | < 0.001 | 0.73 | < 0.001 | < 0.001 |
| P-value for interaction between CPI and presence of emphysema | 0.75 | – | 0.060 | 0.33 | 0.071 |
| HR (95% CI) per 5-point increase in patients with CPFE | – | – | 1.18 (0.99, 1.40) | – | 1.37 (1.15, 1.62) |
| HR (95% CI) per 5-point increase in patients with IPF alone | – | – | 0.99 (0.94, 1.05) | – | 1.16 (1.09, 1.24) |
aHR for CPI > 45. Interaction tests were not carried out for lung transplant due to the small number of events among patients with CPFE