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. 2021 Dec 28;45(1):103–119. doi: 10.1007/s13402-021-00654-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Effect of SPINT2 on CDKN1A (p21) expression is mediated via promotor acetylation. A Chromatin immunoprecipitation of p53 with defined regulatory elements within the CDKN1A promoter. B Nuclear enrichment of p53 after siRNA knockdown of SPINT2. NT: non-targeting siRNA control. Mean and SD of three independent experiments are shown. T test, * p < 0.05; ** p < 0.01. C Representative immunoblot of p53 and p21 in HCT116 and two SPINT2 knockout clones, S15 and S40, after TSA and doxorubicin (DOX) treatment. Ponceau staining was used as a loading control. D, E Quantification of p53 and p21 levels from three independent experiments normalized to the loading control. Mean with SD is shown. T test. * p < 0.05; ** p < 0.01