Fig. 8.
PACS2–TRPV1 axis is required for ER–mitochondrial tethering during ER stress and lung fibrosis. Cartoon summarizing the results of this study: left side: upon ER stress/CHOP induction, SPCΔexon4 overexpression or in IPF AECII where persistent pro-apoptotic ER stress is observed, PACS2 protein is severely decreased and, therefore, a reduction in ER–mitochondrial tethering is observed alongside with severe AECII apoptosis. Upon treatment with CPS, a TRPV1 modulator, PACS2 protein levels are restored, ER–mitochondrial tethering is rescued together with a decrease in AECII apoptosis and COL1A1