Table 1.
Demographic and clinical variables, and measures of psychomotor speed in the MD (N=88) and TRD cohorts (N=57).
| MD (N=88) Primary cohort |
TRD (N=57) Secondary cohort |
p-value | ||
|---|---|---|---|---|
| Age | Mean (SD) | 39.9 (11.6) | 42.8 (9.1) | 0.1161 |
| Sex | N (%) Female | 60 (68.2%) | 38 (66.7%) | 0.8492 |
| Race | N (%) White | 38 (43.2%) | 44 (77.2%) | < 0.0012 |
| BMI | Mean (SD) | 30.9 (7.4) | 31.7 (7.6) | 0.4921 |
| hsCRP (mg/L) | Median (IQR) | 1.5 (3.1) | 2.4 (6.1) | 0.0063 |
| IL-6 (pg/ml) | Median (IQR) | 1.2 (1) | 1.8 (1.4) | 0.0523 |
| HAMD | Median (IQR) | 23 (5) | 23 (5) | 0.1673 |
| Education | N (%) with college degree | 40 (45.5%) | 42 (73.7%) | < 0.0012 |
| TMT | Mean (SD) | 32.4 (13.4) | 32.4 (12.2) | 0.9751 |
| Factor loading | 0.60 | 0.52 | ||
| DSST | Mean (SD) | 53.5 (10.9) | 52.6 (10.1) | 0.5971 |
| Factor loading | −0.60 | −0.54 | ||
| FTT | Mean (SD) | 40.8 (9.4) | 41.0 (9.4) | 0.9431 |
| Factor loading | −0.47 | −0.45 | ||
| SRT | Mean (SD) | 364.3 (72.5) | 368.4 (87.1) | 0.7551 |
| Factor loading | 0.75 | 0.83 | ||
| SMT | Mean (SD) | 557.3 (189.2) | 513.7 (130.5) | 0.1311 |
| Factor loading | 0.59 | 0.77 | ||
| CRT | Mean (SD) | 383.4 (67.5) | 375.9 (66.0) | 0.5121 |
| Factor loading | 0.75 | 0.79 | ||
| CMT | Mean (SD) | 525.8 (130.7) | 501.3 (131.9) | 0.2751 |
| Factor loading | 0.69 | 0.79 |
1
Linear Model ANOVA,
2
Pearson’s Chi-squared test,
3
Kruskal-Wallis rank sum test. SD: standard deviation; BMI: body mass index; HAMD: Total score on 17-item Hamilton Depression Rating Scale; hsCRP: high-sensitivity C-reactive protein (mg/L); IQR: interquartile range; TMT: Trail making test A (s); DSST: Digit Symbol Substitution Task (# of filled boxes correct); FTT: Finger Tapping Task (mean # of taps by dominant hand); SRT: Simple Choice Reaction Time (ms); SMT: Simple Choice Movement Time (ms); CRT: Five Choice Reaction Time (ms); CMT: Five Choice Movement Time (ms). Adapted from Goldsmith, Haroon2.