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. 2022 Feb 15;21:100430. doi: 10.1016/j.bbih.2022.100430

Table 3.

-Multivariate Cox Proportional Hazard model adjusted for age, race, and insurance status - Stratified by Sex

Relationship with Outcome of Anxiety and/or Depression Dx.

Males
Anti-infective agent: HRR 95% CI p value
Any anti-infective prescription 1.46 1.05 2.02 0.024
Any antibiotics 1.45 1.05 1.99 0.022
No antibiotics Reference category
Broad spectrum 1.56 1.12 2.19 0.009
Narrow spectrum 0.71 0.17 2.93 0.639
Topical 1.22 0.72 2.07 0.456
Number of antibiotics (mean ​± ​SD) 1.03 0.94 1.13 0.585
Any antifungal 0.71 0.37 1.35 0.291
Any antiviral
0.82
0.42
1.62
0.574
Females
Any anti-infective prescription 1.08 0.87 1.35 0.495
Any antibiotics 1.08 0.87 1.34 0.507
No antibiotics Reference category
Broad spectrum 1.13 0.89 1.44 0.301
Narrow spectrum 0.59 0.26 1.34 0.205
Topical 1.04 0.74 1.47 0.805
Number of antibiotics (mean ​± ​SD) 1.05 1.00 1.11 0.064
Any antifungal 0.96 0.69 1.34 0.831
Any antiviral 1.15 0.74 1.80 0.528