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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Gastroenterology. 2021 Nov 10;162(3):813–827.e8. doi: 10.1053/j.gastro.2021.11.005

Figure 2.

Figure 2.

Effect of Spd supplementation on DSS colitis. C57BL/6 WT and Smox–/– mice were treated or not with 4% DSS for 5 days and then kept for 5 more days on water alone. Spd was added to the water or to the DSS solution during all the experiments. (A) Colonic polyamine levels measured by LC-MS. (B) Body weights were measured daily and are depicted as percentage of initial body weight. (C) Colons were harvested, washed, and measured. (D-E) Histological injury scores (D) were determined from H&E staining performed on Swiss-rolls of the colon (E); the histologic injury scores of untreated WT and Smox–/– mice ± Spd were all 0 (not shown). Scale Bar, 50 μm. In A-D, *P < . 05, **P < .01, ***P < .001, ****P < .0001 by two-way ANOVA and Tukey test. In B, *P < .05 compared to Smox–/– + DSS + Spd.