Table 1.
Characteristics of Nurses’ Health Study participants with genetic data according to oral hormone therapy use at the midpoint (2000) of follow-up
| Oral hormone therapy use |
|||
|---|---|---|---|
| Never users (n = 3,038) |
Past users (n = 1,368) |
Current users (n = 2,496) |
|
| Age (year), mean (SD) | 64.7 (6.9) | 64.7 (6.9) | 64.7 (6.9) |
| BMIa (kg/m2), mean (SD) | 27.7 (5.8) | 27.1 (5.7) | 26.7 (5.2) |
| Physical activitya, MET-h/wk | 17.7 (21.0) | 17.2 (19.1) | 18.6 (23.1) |
| Alcohol intakea (g/day), mean (SD) | 4.9 (8.9) | 5.6 (9.7) | 5.5 (9.1) |
| Smokinga, % | |||
| Never | 45 | 44 | 45 |
| Former | 44 | 48 | 49 |
| Current | 10 | 8 | 6 |
| Current aspirin usea, (yes) % | 44 | 47 | 49 |
| Paritya, % | |||
| None | 5 | 4 | 4 |
| One | 6 | 6 | 6 |
| More than one | 89 | 90 | 90 |
| Prevalent diagnosisa | |||
| Diabetes, % | 9 | 7 | 6 |
| Hypertension, % | 31 | 34 | 36 |
| Hyperlipidemia, % | 35 | 38 | 34 |
| MI or angina, % | 1 | 2 | 2 |
| Cancer, % | 11 | 17 | 3 |
| Hysterectomya,b, % | 18 | 26 | 34 |
| Age at menopausea (year) mean (SD) | 50.9 (3.6) | 51.2 (3.5) | 51.2 (3.4) |
| Type of menopausea, % | |||
| Natural | 80 | 76 | 72 |
| Surgical | 12 | 16 | 22 |
| Radiation | 2 | 1 | 0 |
| Unknown | 6 | 7 | 6 |
| GRSa,c, % | |||
| Low (Quartile 1) | 26 | 25 | 27 |
| Intermediate (Quartile 2 and 3) | 51 | 51 | 49 |
| High (Quartile 4) | 23 | 25 | 24 |
SD, standard deviation; BMI, body mass index; MET, metabolic equivalent task; MI, myocardial infarction; GRS, genetic risk score.
a
All values of mean (SD) and percentages were standardized to the age distribution of study population.
b
Hysterectomy with or without oophorectomy.
c
GRS was standardized with mean = 0 and SD = 1.