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. 2022 Feb 25;12:3213. doi: 10.1038/s41598-022-07131-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heat map. Fifteen miRNAs with the highest FDR p-value across samples (T1 versus T0) were selected. Each row represents one miRNA, and each column represents one sample. The color represents the difference of the count value to the row mean. They are also called centered values. Red indicates high relative expression, and green indicates low relative expression.