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. 2022 Feb 25;5:173. doi: 10.1038/s42003-022-03118-0

Fig. 1. Late treatment with Compound 9 rescues the AT-1 sTg phenotype.

Fig. 1

a Representative images of WT mice at 2 months of age and AT-1 sTg mice at 2, 4, and 8 months of age. Compound 9 treatment started at 2 months of age. b Lifespan of AT-1 sTg mice on control diet versus Compound 9 diet. c Body weight of AT-1 sTg mice on control diet versus Compound 9 diet. d Representative image (left panel) and weight quantification (right panel) of axillary lymph nodes. e Representative Western blot (left panel) and quantification (right panel) of IgG heavy chain (h.c.) and light chain (l.c.) levels in liver. f Representative images (left panel) and quantification (right panel) of SA-β-Gal staining in liver. g p21 mRNA quantitation in liver. h Representative Western blot (left panel) and quantification (right panel) of p16 levels in liver. Bars represent mean ± SD. *p < 0.05, **p < 0.005, #p < 0.0005 via ordinary two-way ANOVA with Tukey’s multiple comparison test. Black symbol, significance vs WT; Red symbol, significance vs untreated AT-1 sTg.