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. 2022 Feb 25;5:173. doi: 10.1038/s42003-022-03118-0

Fig. 4. ATase inhibitors rescue the AT-1 sTg phenotype.

Fig. 4

a Representative images of WT and AT-1 sTg mice with and without treatment. b Lifespan of WT mice on control diet and AT-1 sTg mice on either control or Compound 10, 11, or 19 diets. Treatment started at weaning. c Quantification of body fat. d Quantification of bone mineral density. e Representative image of spleens. f Quantification of (e). g Representative image of axillary lymph nodes. h Quantification of (g). i Representative Western blot showing IgG heavy chain (h.c.) and light chain (l.c.) levels in liver. j Quantification of (i). For c–j mice were studied at approximately 3 months of age. Bars represent mean ± SD. *p < 0.05, **p < 0.005, ***p < 0.0005, #p < 0.0001 via ordinary two-way ANOVA with Tukey’s multiple comparison test. Black symbol, significance vs WT; Red symbol, significance vs untreated/control diet AT-1 sTg.