Table 2.
Prediction of time to egg clearance using pre-treatment (pre-Tx) enterotypes (ET).
| Outcome | Predictor | HR (95% CI)—ET pre-Tx | P-value | Predictor | HR (95% CI)—ET pre-Tx | P-value |
|---|---|---|---|---|---|---|
| Trichuris trichiura—ALB-IVE | ||||||
| Time to egg clearance | ET 2 | 2.94 (0.18–47.06) | 0.445 | ET 3 | 18.12 (2.33–141.04) | 0.005 |
| (ref = ET1) | Adjusted for | Adjusted for | ||||
| ALB + IVE | Sex | 4.47 (0.27–74.91) | 0.298 | Sex | 29.96 (3.48–258.04) | 0.001 |
| Age | 3.34 (0.19–56.35 | 0.403 | Age | 20.01 (2.46–162.89) | 0.005 | |
| Infection intensity | 2.39 (0.15–38.43) | 0.536 | Infection intensity | 18.69 (2.39–145.98) | 0.005 | |
| Baseline EPG | 2.49 (0.16–40.24) | 0.518 | Baseline EPG | 17.96 (2.3–139.74) | 0.006 | |
| n = 39, events = 13 | ||||||
| Trichuris trichiura—ALB | ||||||
| Time to egg clearance | ET 2 | Not applicable (no patient with ET2 was cured) | ET 3 | 0.61 (0.05–6.69) | 0.683 | |
| (ref = ET1) | Adjusted for | Adjusted for | ||||
| ALB | Sex | Sex | 0.6 (0.05–6.64) | 0.678 | ||
| Age | Age | 0.99 (0.04–22.11) | 0.997 | |||
| Infection intensity | Infection intensity | 0.61 (0.06–6.75) | 0.688 | |||
| Baseline EPG | Baseline EPG | 0.65 (0.06–7.21) | 0.723 | |||
| n = 41, events = 3 | ||||||
| Hookworm—ALB + IVE | ||||||
| Time to egg clearance | ET 2 | 0.53 (0.06–4.56) | 0.565 | ET 3 | 3.75 (1.28–10.98) | 0.016 |
| (ref = ET1) | Adjusted for | Adjusted for | ||||
| Sex | 0.49 (0.06–4.43) | 0.529 | Sex | 3.45 (1.06–11.28) | 0.04 | |
| Age | 1.05 (0.11–10.2) | 0.969 | Age | 5.67 (1.76–18.28) | 0.003 | |
| Infection intensity | 0.56 (0.07–4.83) | 0.599 | Infection intensity | 3.71 (1.26–10.91) | 0.017 | |
| Baseline EPG | 0.48 (0.06–4.13) | 0.505 | Baseline EPG | 3.1 (1.06–9.12) | 0.039 | |
| n = 35, events = 17 | ||||||
| Hookworm—ALB | ||||||
| Time to egg clearance | ET 2 | 1.55 (0.31–7.71) | 0.592 | ET 3 | 1.69 (0.59–4.75) | 0.322 |
| (ref = ET1) | Adjusted for | Adjusted for | ||||
| Sex | 1.57 (0.31–7.81) | 0.584 | Sex | 1.88 (0.63–5.59) | 0.257 | |
| Age | 1.62 (0.29–8.7) | 0.577 | Age | 1.78 (0.52–6.05) | 0.357 | |
| Infection intensity | 1.55 (0.31–7.75) | 0.591 | Infection intensity | 1.67 (0.59–4.7) | 0.332 | |
| Baseline EPG | 1.72 (0.34–8.72) | 0.514 | Baseline EPG | 1.64 (0.58–4.61) | 0.350 | |
| n = 34, events = 23 | ||||||
Clearance is defined as two consecutive samples with no eggs (Trichuris trichiura or hookworm) detected and an average egg count between days 14 and 28 equal to zero. A significant hazard ratio above one indicates that the patient is reaching the event (clearance of eggs) at a faster rate. ALB-IVE albendazole and Ivermectin, ALB albendazole, ref. reference category, HR (95% CI) hazard ratio (95% confidence interval), Tx treatment.