Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 25;13:1059. doi: 10.1038/s41467-022-28695-w

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a–c Overlapping binding sites of Orc6-CB_N with Mcm2-7 in the Mcm2-7·ORC complex (MO, PDB 6rqc⁵⁷) and with Orc1 and Cdc6 in ScORC·DNA·Cdc6. a Orc6-CB_N binds to Mcm2 and Mcm6 in the MO complex. Mcm2, Mcm6, and Orc6 are depicted as colored cartoon, while other Mcm2-7 subunits are shown in light gray as transparent cartoon. Other ORC subunits are omitted for clarity. b Structural alignment of Orc6-CB_N in the MO complex with this domain in ScORC·DNA·Cdc6. The root mean square deviation (RMSD) of atomic coordinates is listed. c Zoomed view of boxed region in a with Orc6-CB_N from ScORC·DNA·Cdc6 (shown as surface) superposed onto the corresponding domain in the MO complex (shown as cartoon). The Orc6-CB_N surface involved in interactions with Cdc6 and Orc1 in ScORC·DNA·Cdc6 is colored purple. d and e Orc6-CB_N in ScORC·DNA·Cdc6 occupies a similar position as the winged-helix domain (WH) of Mcm7 in the OCCM complex. d Superposition of ScORC·DNA·Cdc6 (this study) and OCCM (PDB 5v8f⁸) by structural alignment of Orc1 in both complexes. Mcm2-7 and Cdt1 are represented as surface except for the Mcm2-7 WH domains (in blue cartoon), while ORC and Cdc6 are depicted as cartoon. e Zoomed view of boxed region from d highlights that the Mcm7-WH domain (as positioned in the OCCM complex) would clash with Orc6-CB_N that is docked onto the ORC·Cdc6 ring. Mcm7-WH is rendered as blue surface, while other OCCM regions are omitted for clarity. ScORC·DNA·Cdc6 (this study) is shown as cartoon with Orc1, Orc6, and Cdc6 colored.