Figure 5.

(A) Diagnostic algorithm and (B) algorithm for treatment and follow-up of grade 4 DIILD in cancer patients. Grade 4 DIILD definition is adapted from the Common Terminology Criteria for Adverse Events (CTCAE), Version 5.0 (27 November 2017).²⁸

BAL, bronchoalveolar lavage; CRP, C-reactive protein; DIILD, drug-induced interstitial lung disease; DLCO, diffusing capacity of lung for carbon monoxide; ESR, erythrocyte sedimentation rate; FIO₂, fraction of inspired oxygen; HRCT, high-resolution computed tomography; KL-6, Krebs von den Lungen-6; LDH, lactate dehydrogenase; PaO₂, arterial partial pressure of oxygen; SpO₂, oxygen saturation by pulse oximetry; TMP-SMX, trimethoprim/sulfamethoxazole.