Table 3.
Associations between adherence to PCA components and all breast cancer, ER + breast cancer and ER- breast cancer risk. Components are used in continuous and in quintiles in logistic regression models. Odds Ratio (OR) and 95% Confidence Intervals (CI) are presented
| All breast cancer | ER + breast cancer | ER- breast cancer | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number (%)—Control | Number (%)—Cases | OR [95% CI] | p-value | Number (%)—Control | Number (%)—Cases | OR [95% CI] | p-value | Number (%)—Control | Number (%)—Cases | OR [95% CI] | p-value | |
| N = 194 | N = 194 | N = 194 | N = 132 | N = 194 | N = 26 | |||||||
| Component 1, continuous | 194 (100.00) | 194 (100.00) | 1.01 [0.82; 1.25] | 0.9208 | 194 (100.00) | 132 (100.00) | 1.03 [0.81; 1.31] | 0.8068 | 194 (100.00) | 26 (100.00) | 0.74 [0.41; 1.33] | 0.3169 |
| Component 1, quintiles | 0.2800 | 0.5932 | 0.0566 | |||||||||
| Quintile 1 | 45 (23.20) | 32 (16.49) | Reference | 45 (23.20) | 26 (19.70) | Reference | 45 (23.20) | 3 (11.54) | Reference | |||
| Quintile 2 | 33 (17.01) | 45 (23.20) | 2.24 [1.09; 4.60] | 33 (17.01) | 29 (21.97) | 1.55 [0.70; 3.44] | 33 (17.01) | 7 (26.92) | 5.90 [0.83; 41.99] | |||
| Quintile 3 | 40 (20.62) | 38 (19.59) | 1.55 [0.75; 3.20] | 40 (20.62) | 22 (16.67) | 1.12 [0.50; 2.52] | 40 (20.62) | 8 (30.77) | 4.57 [0.71; 29.61] | |||
| Quintile 4 | 40 (20.62) | 38 (19.59) | 1.38 [0.67; 2.84] | 40 (20.62) | 22 (16.67) | 1.05 [0.46; 2.35] | 40 (20.62) | 7 (26.92) | 3.43 [0.55; 21.20] | |||
| Quintile 5 | 36 (18.56) | 41 (21.13) | 1.65 [0.80; 3.40] | 36 (18.56) | 33 (25.00) | 1.86 [0.86; 4.03] | 36 (18.56) | 1 (3.85) | 0.11 [0.01; 2.31] | |||
| Component 2, continuous | 194 (100.00) | 194 (100.00) | 0.97 [0.78; 1.21] | 0.8043 | 194 (100.00) | 132 (100.00) | 1.04 [0.81; 1.34] | 0.7578 | 194 (100.00) | 26 (100.00) | 1.31 [0.77; 2.23] | 0.3136 |
| Component 2, quintiles | 0.6753 | 0.7218 | 0.3073 | |||||||||
| Quintile 1 | 38 (19.59) | 39 (20.10) | Reference | 38 (19.59) | 24 (18.18) | Reference | 38 (19.59) | 1 (3.85) | Reference | |||
| Quintile 2 | 43 (22.16) | 35 (18.04) | 0.76 [0.38; 1.54] | 43 (22.16) | 22 (16.67) | 0.80 [0.35; 1.81] | 43 (22.16) | 7 (26.92) | 10.46 [0.85; 128.74] | |||
| Quintile 3 | 35 (18.04) | 43 (22.16) | 0.93 [0.46; 1.89] | 35 (18.04) | 31 (23.48) | 1.13 [0.51; 2.51] | 35 (18.04) | 6 (23.08) | 4.45 [0.37; 53.96] | |||
| Quintile 4 | 37 (19.07) | 41 (21.13) | 1.07 [0.53; 2.17] | 37 (19.07) | 29 (21.97) | 1.22 [0.55; 2.72] | 37 (19.07) | 7 (26.92) | 8.31 [0.69;100.26] | |||
| Quintile 5 | 41 (21.13) | 36 (18.56) | 0.66 [0.31; 1.39] | 41 (21.13) | 26 (19.70) | 0.91 [0.39; 2.13] | 41 (21.13) | 5 (19.23) | 3.24 [0.22; 46.87] | |||
| Component 3, continuous | 194 (100.00) | 194 (100.00) | 1.09 [0.88; 1.36] | 0.4141 | 194 (100.00) | 132 (100.00) | 1.19 [0.93; 1.51] | 0.1702 | 194 (100.00) | 26 (100.00) | 1.20 [0.76; 1.88] | 0.4374 |
| Component 3, quintiles | 0.0882 | 0.0397 | 0.5452 | |||||||||
| Quintile 1 | 45 (23.20) | 32 (16.49) | Reference | 45 (23.20) | 18 (13.64) | Reference | 45 (23.20) | 6 (23.08) | Reference | |||
| Quintile 2 | 39 (20.10) | 39 (20.10) | 1.33 [0.66; 2.66] | 39 (20.10) | 23 (17.42) | 1.40 [0.61; 3.24] | 39 (20.10) | 4 (15.38) | 1.03 [0.18; 6.04] | |||
| Quintile 3 | 37 (19.07) | 41 (21.13) | 1.72 [0.86; 3.48] | 37 (19.07) | 33 (25.00) | 2.61 [1.16; 5.88] | 37 (19.07) | 4 (15.38) | 1.88 [0.34; 10.58] | |||
| Quintile 4 | 29 (14.95) | 49 (25.26) | 2.47 [1.21; 5.06] | 29 (14.95) | 34 (25.76) | 3.06 [1.36; 6.89] | 29 (14.95) | 7 (26.92) | 3.18 [0.66; 15.45] | |||
| Quintile 5 | 44 (22.68) | 33 (17.01) | 1.09 [0.54; 2.21] | 44 (22.68) | 24 (18.18) | 1.59 [0.70; 3.61] | 44 (22.68) | 5 (19.23) | 0.97 [0.18; 5.18] | |||
| Component 4, continuous | 194 (100.00) | 194 (100.00) | 0.93 [0.74; 1.18] | 0.5660 | 194 (100.00) | 132 (100.00) | 0.91 [0.70; 1.19] | 0.4861 | 194 (100.00) | 26 (100.00) | 0.71 [0.41; 1.23] | 0.2170 |
| Component 4, quintiles | 0.1077 | 0.0531 | 0.6901 | |||||||||
| Quintile 1 | 39 (20.10) | 38 (19.59) | Reference | 39 (20.10) | 25 (18.94) | Reference | 39 (20.10) | 6 (23.08) | Reference | |||
| Quintile 2 | 39 (20.10) | 39 (20.10) | 1.26 [0.62; 2.53] | 39 (20.10) | 26 (19.70) | 1.15 [0.51; 2.56] | 39 (20.10) | 6 (23.08) | 1.41 [0.27; 7.52] | |||
| Quintile 3 | 30 (15.46) | 48 (24.74) | 1.94 [0.93; 4.03] | 30 (15.46) | 37 (28.03) | 2.14 [0.94; 4.89] | 30 (15.46) | 6 (23.08) | 1.37 [0.23; 8.13] | |||
| Quintile 4 | 43 (22.16) | 35 (18.04) | 0.89 [0.43; 1.83] | 43 (22.16) | 22 (16.67) | 0.80 [0.34; 1.85] | 43 (22.16) | 5 (19.23) | 0.65 [0.10; 4.12] | |||
| Quintile 5 | 43 (22.16) | 34 (17.53) | 0.79 [0.37; 1.65] | 43 (22.16) | 22 (16.67) | 0.69 [0.29; 1.66] | 43 (22.16) | 3 (11.54) | 0.45 [0.07; 2.79] | |||
All models are adjusted on age at blood draw (continuous), body mass index at blood draw (kg/m2, continuous), year of blood draw (continuous), total plasma lipid content (ng/L, continuous), smoking status (never vs. ever), physical activity measured in metabolic equivalent tasks (MET)-hour/week (continuous), education (≤ 12 years, 12 to 14 years, > 14 years), personal history of benign breast disease (no vs. yes), and family history of breast cancer (none, in first-degree relatives, in extended relatives), parity and age at first fullterm pregnancy (FFTP) (no children, 1 or 2 children and < 30 years old at FFTP, ≥ 3 children and < 30 years old at FFTP, ≥ 30 years old at FFTP), total breastfeeding duration (never, ≤ 6 or > 6 months), age at menarche years, continuous), current use of menopausal hormone therapy (yes, no), use of oral contraceptives (ever vs. never), menopausal status and age at menopause (menopause before age 51, menopause at age 51 or later)