Table 2.
Differences of immune cells levels estimated by xCell algorithm
| Immune cells | Average | F value | P value | ||
|---|---|---|---|---|---|
| co-low | single-high | co-high | |||
| aDC | 0.080 | 0.108 | 0.097 | 2.582 | 0.079 |
| Adipocytes | 0.108 | 0.076 | 0.031 | 3.456 | 0.034 |
| Astrocytes | 0.040 | 0.087 | 0.106 | 13.338 | 0.000 |
| B cells | 0.108 | 0.111 | 0.062 | 0.538 | 0.585 |
| Basophils | 0.038 | 0.012 | 0.007 | 6.142 | 0.003 |
| CD4 + memory T cells | 0.137 | 0.125 | 0.107 | 1.028 | 0.360 |
| CD4 + naïve T cells | 0.060 | 0.064 | 0.045 | 0.577 | 0.563 |
| CD4 + T cells | 0.004 | 0.002 | 0.000 | 0.622 | 0.538 |
| CD4 + Tcm | 0.006 | 0.004 | 0.003 | 2.194 | 0.115 |
| CD4 + Tem | 0.014 | 0.011 | 0.011 | 0.850 | 0.429 |
| CD8 + naïve T cells | 0.008 | 0.009 | 0.007 | 1.943 | 0.146 |
| CD8 + T cells | 0.034 | 0.015 | 0.011 | 10.264 | 0.000 |
| CD8 + Tcm | 0.022 | 0.014 | 0.010 | 3.071 | 0.049 |
| CD8 + Tem | 0.003 | 0.002 | 0.000 | 2.196 | 0.114 |
| cDC | 0.026 | 0.022 | 0.019 | 0.701 | 0.498 |
| Chondrocytes | 0.126 | 0.161 | 0.163 | 4.418 | 0.013 |
| Class switched memory B cells | 0.034 | 0.025 | 0.020 | 1.493 | 0.228 |
| CLP | 0.048 | 0.042 | 0.044 | 1.146 | 0.320 |
| CMP | 0.000 | 0.000 | 0.000 | 1.071 | 0.345 |
| DC | 0.060 | 0.071 | 0.056 | 1.160 | 0.316 |
| Endothelial cells | 0.142 | 0.143 | 0.145 | 0.010 | 0.990 |
| Eosinophils | 0.030 | 0.036 | 0.038 | 3.502 | 0.032 |
| Epithelial cells | 0.726 | 0.891 | 0.918 | 7.364 | 0.001 |
| Erythrocytes | 0.000 | 0.000 | 0.000 | 0.943 | 0.391 |
| Fibroblasts | 0.121 | 0.138 | 0.137 | 0.559 | 0.573 |
| GMP | 0.004 | 0.002 | 0.000 | 2.493 | 0.086 |
| Hepatocytes | 0.085 | 0.090 | 0.098 | 0.516 | 0.598 |
| HSC | 0.196 | 0.221 | 0.215 | 1.009 | 0.367 |
| iDC | 0.119 | 0.131 | 0.114 | 0.591 | 0.555 |
| Keratinocytes | 0.092 | 0.137 | 0.142 | 5.336 | 0.006 |
| Ly Endothelial cells | 0.154 | 0.157 | 0.154 | 0.016 | 0.984 |
| Macrophages | 0.054 | 0.074 | 0.072 | 2.933 | 0.056 |
| Macrophages M1 | 0.046 | 0.065 | 0.065 | 5.435 | 0.005 |
| Macrophages M2 | 0.015 | 0.017 | 0.013 | 1.055 | 0.350 |
| Mast cells | 0.032 | 0.029 | 0.024 | 3.281 | 0.040 |
| Megakaryocytes | 0.014 | 0.014 | 0.012 | 1.286 | 0.279 |
| Melanocytes | 0.013 | 0.012 | 0.011 | 0.447 | 0.640 |
| Memory B cells | 0.015 | 0.016 | 0.009 | 0.305 | 0.738 |
| MEP | 0.035 | 0.030 | 0.027 | 1.792 | 0.170 |
| Mesangial cells | 0.081 | 0.093 | 0.106 | 8.969 | 0.000 |
| Monocytes | 0.021 | 0.033 | 0.021 | 2.337 | 0.100 |
| MPP | 0.000 | 0.000 | 0.000 | 0.056 | 0.945 |
| MSC | 0.140 | 0.265 | 0.310 | 28.875 | 0.000 |
| Mv Endothelial cells | 0.052 | 0.057 | 0.059 | 0.483 | 0.618 |
| Myocytes | 0.006 | 0.005 | 0.004 | 1.011 | 0.366 |
| Naïve B cells | 0.010 | 0.013 | 0.007 | 0.398 | 0.672 |
| Neurons | 0.066 | 0.015 | 0.014 | 17.406 | 0.000 |
| Neutrophils | 0.001 | 0.001 | 0.001 | 0.094 | 0.910 |
| NK cells | 0.000 | 0.000 | 0.000 | 0.458 | 0.633 |
| NKT | 0.024 | 0.022 | 0.026 | 0.959 | 0.385 |
| Osteoblast | 0.077 | 0.036 | 0.034 | 10.543 | 0.000 |
| pDC | 0.072 | 0.058 | 0.046 | 1.981 | 0.141 |
| Pericytes | 0.074 | 0.099 | 0.115 | 3.779 | 0.025 |
| Plasma cells | 0.011 | 0.008 | 0.005 | 6.987 | 0.001 |
| Platelets | 0.001 | 0.000 | 0.000 | 7.379 | 0.001 |
| Preadipocytes | 0.009 | 0.002 | 0.001 | 3.916 | 0.022 |
| Pro B cells | 0.002 | 0.002 | 0.001 | 0.319 | 0.727 |
| Sebocytes | 0.408 | 0.533 | 0.534 | 4.005 | 0.020 |
| Skeletal muscle | 0.000 | 0.000 | 0.000 | 2.332 | 0.100 |
| Smooth muscle | 0.386 | 0.332 | 0.333 | 12.517 | 0.000 |
| Tgd cells | 0.000 | 0.000 | 0.000 | 0.263 | 0.769 |
| Th1 cells | 0.058 | 0.046 | 0.047 | 1.671 | 0.191 |
| Th2 cells | 0.009 | 0.010 | 0.009 | 0.041 | 0.960 |
| Tregs | 0.016 | 0.011 | 0.009 | 3.210 | 0.043 |
Abbreviations: aDC Activated dendritic cells, CD4 + Tcm, CD4 + central memory T-cells, CD4 + Tem CD4 + effector memory T-cells, CD8 + Tcm CD8 + central memory T-cells, CD8 + Tem CD8 + effector memory T-cells, cDC Xonventional dendritic cells, CLP Common lymphoid progenitors, CMP Common myeloid progenitors, DC Dendritic cells, GMP Granulocyte–macrophage progenitors, HSC Hematopoietic stem cells, iDC Immature dendritic cells, ly endothelial cells Lymphatic endothelial cells, MEP Megakaryocyte–erythroid progenitors, MPP Multipotent rogenitors, MSC Mesenchymal stem cells, mv endothelial cells Microvascular endothelial cells, NKT Natural killer T-cells, pDC Plasmacytoid dendritic cells, Tgd cells Gamma delta T-cells, Th1 cells Type 1 T-helper cells, Th2 cells Type 2 T-helper cells, Tregs Regulatory T-cells