Table 4.
Clinical data of adult patients with GSD Ia-related gout and primary gout
| Variable | GSD Ia-related gout (n = 31) | Primary gout (n = 93) | P |
|---|---|---|---|
| Female | 11 (35.5) | 2 (2.2) | < 0.001* |
| Age, years | 25 (19, 41) | 34 (18, 43) | 0.001* |
| Gout symptom onset age, years | 18 (10, 29) | 28 (14, 41) | 0.001* |
| Family history of HUA | 2 (6.5) | 16 (17.2) | 0.141 |
| Gout symptom duration, years | 5.0 ± 4.4 | 5.0 ± 4.5 | 0.997 |
| Comorbidities | |||
| Hypertension | 0 (0) | 28 (30.1) | 0.001* |
| Diabetes mellitus | 0 (0) | 6 (6.5) | 0.335 |
| Hyperlipidaemia | 31 (100) | 50 (53.8) | < 0.001* |
| Site of first gouty attack | |||
| Ankle | 14 (45.2) | 34 (36.6) | 0.394 |
| MTP1 | 12 (38.7) | 55 (59.1) | 0.048* |
| Knee | 2 (6.5) | 3 (3.2) | 0.429 |
| Hand joints | 2 (6.5) | 1 (1.1) | 0.092 |
| Elbows | 1 (3.2) | 0 (0) | 0.250 |
| Number of involved joints | 3.5 ± 2.0 | 3.7 ± 2.9 | 0.053 |
| Upper extremity involved | 15 (48.4) | 29 (31.2) | 0.083 |
| Presence of tophi | 15 (48.4) | 24 (25.8) | 0.019* |
| Presence of renal calculi | 15 (48.4) | 20 (21.5) | 0.004* |
| Proteinuria | 13 (41.9) | 2 (2.2) | < 0.001* |
| Haematuria | 8 (25.8) | 1 (1.1) | < 0.001* |
| Renal insufficiency | 2 (6.5) | 1 (1.1) | 0.092 |
| Maximum value of sUA, umol/L | 800.5 ± 131.0 | 584.3 ± 112.8 | 0.001* |
| TG, mmol/L | 12.4 ± 10.5 | 2.9 ± 1.7 | 0.003* |
| TC, mmol/L | 7.1 ± 2.9 | 3.6 ± 1.5 | 0.001* |
| LDL-C, mmol/L | 3.3 ± 1.2 | 2.8 ± 1.0 | 0.546 |
| FBS, mmol/L | 2.9 ± 0.7 | 5.5 ± 4.2 | 0.500 |
| BMI, kg/m2 | 21.4 ± 4.1 | 27.4 ± 3.4 | 0.001* |
Abbreviation: GSD Ia glycogen storage disease type Ia, HUA hyperuricaemia, MTP1 first metatarsophalangeal, SUA serum uric acid, TG triglycerides, TC total cholesterol, LDL-C low-density lipoprotein cholesterol, FBS fasting blood sugar, BMI body mass index
*P < 0.05