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. 2022 Feb 25;20:104. doi: 10.1186/s12967-022-03303-z

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Gene expression profiling by RNA-seq among CD4⁺-T cells treated with L. acidophilus, FK506, and combination. a Hierarchical cluster heatmap of mouse anti-CD3 stimulated CD4⁺-T cells treated with L. acidophilus and/or FK506. b Significantly differentially expressed genes and c significant differences in Th1, Th17, and Treg populations and mTOR and JAK-STAT pathway activities versus only anti-CD3–treated CD4⁺-T cells