Fig. 4.

The order parameter, $S_{\mathit{CD}}$ of a $sn-2$ and b $sn-1$ acyl chains of POPC corresponding to SS47-52 (blue triangle), SS-free peptide (grey square) and control POPC (black circle) systems are shown. The membrane thickness maps upon interaction of c SS47-52 and d SS-free states of HAV-2B peptide with POPC bilayer are generated considering inter-leaflet P–P distance with 2 Å resolution along the xy-plane. The localization of e SS47-52 and f SS-free peptide on POPC bilayer are shown. The membrane thinning effect is localized around the insertion site of SS47-52 peptide, whilst more pronounced uniform global thinning effect is observed upon SS-free HAV-2B peptide partitioning