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Postulated mechanism of increased SARS-CoV-2 infection and worsened clinical outcomes in PCOS. In PCOS, elevated androgens upregulate the SARS-CoV-2 receptor ACE2 and modify host proteases to increase SARS-CoV-2 viral entry into tissues. The Up arrow signifies increase(s); the lightning bolt represents injury (from Lizneva et al. [122, 123], with permission of CC-Creative Commons License Deed)
