TABLE 7.
Summary of findings: Aspirin compared to Placebo/Other NSAIDs for Pediatric ARTI
|
Patient or population: Pediatric ARTI Intervention: Aspirin Comparison: Placebo/Other NSAIDs | ||||||
|---|---|---|---|---|---|---|
|
Outcome № of participants (studies) |
Relative effect (95% CI) |
Anticipated absolute effects (95% CI) | Certainty | What happens | ||
| Difference | ||||||
|
Fever Reduction follow up: 6 hours № of participants: 28 (1 RCT) |
– | The mean fever Reduction was 0.86 (0.21) degree | – |
MD 0.33 degree lower (0.13 lower to 0.55 lower) |
⨁⨁⨁◯ MODERATE a |
Aspirin probably results in a large reduction in fever. |
|
Cough follow up: 3 days № of participants: 70 (1 RCT) |
– | The mean cough was 2.00 (0.15) (0–3 severity score) | – |
MD 0.14 (0‐3 severity score) lower (0.22 lower to 0.06 higher) |
⨁⨁⨁◯ MODERATE b |
Aspirin does not reduce cough. |
| Sore Throat ‐ not reported | – | – | – | – | – | No studies investigated efficacy of Aspirin in pediatric sore throat pain relief. |
| ARDS ‐ not reported | – | – | – | – | – | No studies investigated efficacy of Aspirin in pediatric ARDS related outcomes. |
| Length of Stay ‐ not reported | – | – | – | – | – | No studies investigated efficacy of Aspirin in pediatric hospitalization and length of stay. |
|
Gastrointestinal adverse events (GI AE) follow up: 7 days № of participants: 98 (2 RCTs) |
not pooled | 0.0% | not pooled | not pooled |
⨁◯◯◯ VERY LOW a,b,c |
The evidence is very uncertain about the effect of aspirin on gastrointestinal adverse events. |
GRADE Working Group grades of evidence:
High certainty: We are very confident that the true effect lies close to that of the estimate of the effect
Moderate certainty: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low certainty: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
Very low certainty: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect
Explanations: a. lacking information on allocation and randomization, also the intervention was not blinded to participants nor the examiners;
b. blinding, randomization and concealment not explained and c. very small sample sizes.
Abbreviations: CI, Confidence interval; MD, Mean difference.
The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).