Table 3.
The Clinical Application of These Prediction Models. After Inputting the Variables into the Predicted Models, These Models Finally Output the Predicted C0/D Values
| Name | Input Variables | Output (ng/mL/(mg/kg)) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Whole group (GBDT model) | |||||||||||
| ALB0 (g/l) | MYH9rs2239781_CT | CTLA4rs4553808_AA | CYP3A5*3/*3 | MYH9rs2239781_CC | / | / | / | / | / | ||
| X1 | 33.2 | 0 | 1 | 0 | 0 | / | / | / | / | 72.286 | |
| Y1 | 13.2 | 1 | 1 | 0 | 0 | / | / | / | / | 52.771 | |
| CYP3A5 expresser group (ET model) | |||||||||||
| AGE0 (y) | MYH9rs2239781_CC | MAP3K11rs7946115_CG | CTLA4rs4553808_GG | / | / | / | / | / | / | ||
| X2 | 4.9 | 0 | 1 | 0 | / | / | / | / | / | 51.082 | |
| Y2 | 6.4 | 0 | 0 | 0 | / | / | / | / | / | 60.876 | |
| CYP3A5 nonexpresser group (GBDT model) | |||||||||||
| MYH9rs2239781_CC | MYH9rs4821478_AA | INF2rs1128880_TT | GENDER | ACTN4rs56113315_CT | ACTN4rs3745859_CT | ACTN4rs62121818_CC | INF2rs1128880_GT | IL2RArs12722489_CT | / | ||
| X3 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 106.600 | |
| Y3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 117.945 | |
Notes: Xn~Yn are names of patients. C0/D means the TAC dose/weight-adjusted trough concentrations. 0 represents that the patient does not carry the genotype, and 1 represents that the patient carries the genotype.