Langhans 2017.

Trial name or title	A Randomized Study of Localization of Nonpalpable Breast Lesions ‐ RSL vs WGL
Methods	Allocation: randomized Endpoint classification: efficacy study Intervention model: parallel assignment Masking: open label Primary purpose: treatment
Participants	Inclusion criteria: participants with nonpalpable breast lesions, carcinoma in situ or invasive carcinoma, where preoperative lesion localization is necessary; all age groups, minimum 18 years. Exclusion criteria: participants with benign nonpalpable breast lesions; participants who are unable to comprehend the information; participants who are pregnant, breastfeeding or have children < 3 years; participants who have lesions, which requires more than two wires or seeds for localization.
Interventions	RSL versus WGL
Outcomes	Primary: re‐operation rate due to positive microscopic margins detected at the final pathological evaluation. Secondary: amount of excised breast tissue in relation to tumour size. Other: duration of the surgical procedure.
Starting date	January 2014
Contact information	linnea.langhans@regionh.dk
Notes	Recruiting

RSL: radioactive seed localization
 WGL: wire‐guided localization