Table 2:
Primary and Re-treatment Characteristics
| Characteristic | All N (%) /M (Range) | No Re-RT N (%) /M (Range) | Re-RT N (%) /M (Range) |
|---|---|---|---|
| Initial Treatment Per Protocol | |||
| D9803 | 5 (22) | 1 (4) | 4 (17) |
| ARST-0531 | 5 (22) | 3 (13) | 2 (9) |
| ARST-08P1 | 2 (9) | 0 | 2 (9) |
| ARST-0331 | 3 (13) | 1 (4) | 2 (9) |
| IRS-IV | 1 (4) | 1 (4) | 0 |
| ARST-0431 | 2 (9) | 1 (4) | 1 (4) |
| Non-Protocol Treatment Plan | 5 (22) | 4 (17) | 1 (4) |
| Initial Surgical Extent | |||
| No resection | 15 (65) | 10 (43) | 5 (22) |
| Subtotal resection, gross residual disease | 3 (13) | 1 (4) | 2 (9) |
| Subtotal resection, microscopic residual disease | 1 (4) | 0 | 1 (4) |
| Gross total resection | 1 (4) | 0 | 1 (4) |
| Gross total resection with DPE | 3 (13) | 0 | 3 (13) |
| Initial Surgery Type | |||
| Wide Local Excision | 5 (22) | 1 (4) | 4 (17) |
| Composite Resection | 3 (13) | 0 | 3 (13) |
| Initial RT | |||
| Dose (Gy) | 50.4 (24–54) | 50.4 (36–50.4) | 50.4 (24–50.4) |
| Salvage Chemo | |||
| Yes | 23 (100) | 11 (48) | 12 (52) |
| Re-RT | |||
| Yes | 12 (52) | 0 (0) | 12 (52) |
| Dose (Gy) | - | - | 41.4 (36–59.4) |
| Salvage Surgery | |||
| Unresected or Subtotal resection | 8 (35) | 3 (13) | 5 (22) |
| Gross total resection | 4 (17) | 1 (4) | 3 (13) |
No Re-RT = unirradiated at relapse, Re-RT = re-irradiated at relapse, M = median, DPE = delayed primary excision, RT = radiotherapy, Gy = Gray.