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. 2022 Feb 17;4(1):fcac039. doi: 10.1093/braincomms/fcac039

Figure 5.

Figure 5

Imbalance in the levels of syndapin-2 in brain microvessels is associated with ageing. (A1) Immunoblotting for syndapin-2, Rab5 and GAPDH (as loading control) in the microvessel fractions of 4- and 12-months-old WT mouse brains. Expression of (A2) syndapin-2 and (A3) Rab5 in microvessels of WT mouse brains. Data normalized to GAPDH. Violin plot of n = 4 animals. ***P < 0.001, Student’s t-test. (B) Ratio of syndapin-2/Rab5 in WT brain microvessels. Floating bars of n = 4 animals. *P < 0.05, Student’s t-test. (B1) Immunoblotting for syndapin-2, Rab5 and GAPDH (loading control) in the microvessels of 4- and 12-months-old APP-PS1 mouse brains. Expression of (C2) syndapin-2 and (C3) Rab5 in the APP-PS1 brain microvessels. Data normalized to GAPDH. Violin plot of n = 4 animals. *P < 0.05, ***P < 0.001, Student’s t-test. (D) Ratio of syndapin-2/Rab5 in APP-PS1 microvessels. Floating bars of n = 4 animals. **P < 0.01, Student’s t-test. For full blots of the data represented in A–D, see Supplementary Fig. 10.