Figure 1:

Miropin inhibits plasmin but not coagulation cascade proteases. A) Human plasmin and thrombin were incubated with a 10-molar excess of miropin, and their residual activitieswere determined. B) Plasma was preincubated with miropin, and the prothrombin time (PT) and activated partial thromboplastin time (APTT) were evaluated using a C-2 dual channel coagulometer. In both panels, the data shown are the means and standard deviations of the means from three replicates.