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. 2022 Jan 11;59(3):1693–1705. doi: 10.1007/s12035-021-02686-2

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© The Author(s) 2022

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Fig. 1 — Schematic representation of the experimental design. Postmortem human tissue samples used in this study were collected from ALS cases (n = 7) and age- and sex-matched control cases (n = 7). RNA-Seq was performed on RNA extracted from the pyramidal tract of the medulla oblongata. Differential expression analysis of small RNAs was performed, followed by validation