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. 2022 Jan 11;59(3):1693–1705. doi: 10.1007/s12035-021-02686-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Immunohistochemistry for PIWIL1 in the lumbar spinal cord of control (A) and ALS (B–E) patients. A In control patients, cell nuclei, the nuclear membrane (small arrows), and cell bodies of anterior horn cells (AHCs) are immunopositive for PIWIL1. B. In ALS patients, some remaining AHCs have nuclei positive for PIWIL1 (white arrow), while others have PIWIL1-negative nuclei (black arrow). C–E. In double immunofluorescence staining, PIWIL1 is co-localized with intracytoplasmic inclusions positive for TDP-43 (white arrows) in ALS patients. Scale bar = 20 µm