Table 1.
Patient Characteristics
| Characteristic | China | South America | U.S. | otherf | all infected patients | all | P g |
|---|---|---|---|---|---|---|---|
| n | 485 (49) | 170 (17) | 284 (29) | 52 (5) | 502 (51) | 991 | |
| age, median (IQR) | 60 (46, 69) | 63 (42, 73) | 63 (50, 73) | 67 (55, 76) | 62 (47, 71) | 62 (47, 72) | 0·029 |
| sex, male | 323 (67) | 102 (60) | 144 (51) | 29 (56) | 297 (59) | 598 (60) | <0·0001 |
| Charlson comorbidity index, median (IQR)a | 1 (0, 2) | 1 (0, 3) | 3 (1, 5) | 2 (1, 4) | 2 (0, 4) | 1 (0, 3) | <0·0001 |
| Pitt Bacteremia Score, median (IQR)b | 2 (0, 4) | 2 (0, 4) | 2 (1, 5) | 1 (0, 3) | 2 (0, 4) | 2 (0, 4) | 0·0002 |
| intensive care unitc | 263 (54) | 44 (26) | 101 (36) | 25 (48) | 202 (40) | 433 (44) | <0·0001 |
| time to positive culture, days, median (IQR)d | 8 (2, 18) | 8 (1, 22) | 2 (0, 17) | 15 (3, 34) | 8 (1, 22) | 7 (1, 19) | <0·0001 |
| admitted frome | <0·0001 | ||||||
| home | 171 (35) | 125 (74) | 127 (45) | 43 (83) | 250 (50) | 466 (47) | |
| hospital transfer | 310 (64) | 43 (25) | 50 (18) | 4 (8) | 194 (39) | 407 (41) | |
| long-term chronic care | 3 (1) | 0 | 80 (28) | 2 (4) | 44 (9) | 85 (9) | |
| long term acute care | 0 | 0 | 26 (9) | 2 (4) | 11 (2) | 28 (3) | |
| transferred from foreign country | 0 | 0 | 1 (0) | 1 (2) | 2 (0) | 2 (0) | |
| hospice | 1 (0) | 1 (0) | 0 | 0 | 1 (0) | 2 (0) | |
| culture | <0·0001 | ||||||
| blood: infection | 41 (8) | 34 (20) | 49 (17) | 6 (12) | 130 (26) | 130 (13) | |
| urine: infection | 30 (6) | 38 (22) | 41 (14) | 4 (8) | 113 (23) | 113 (11) | |
| urine: colonization | 32 (7) | 36 (21) | 74 (26) | 10 (19) | 152 (15) | ||
| respiratory: infection | 118 (24) | 5 (3) | 14 (5) | 1(2) | 138 (27) | 138 (14) | |
| respiratory: colonization | 184 (38) | 11 (6) | 50 (18) | 2 (4) | 247 (25) | ||
| wound: infection | 11 (2) | 13 (8) | 13 (5) | 0 | 37 (7) | 37 (4) | |
| wound: colonization | 5 (1) | 10 (6) | 23 (8) | 3 (6) | 41 (4) | ||
| intra-abdominal: infection | 46 (9) | 18 (11) | 13 (5) | 5 (10) | 82 (16) | 82 (8) | |
| other: infection | 0 | 1 (1) | 0 | 1 (2) | 2 (0) | 2 (0) | |
| other: colonization | 18 (4) | 4 (2) | 7 (2) | 20 (38) | 49 (5) |
All data is shown as n (%) unless otherwise specified.
Charlson comorbidity index. is a chronic comorbidity score with a range from 0 to 37, with higher scores indicating the presence of more comorbid conditions. A patient with a score of 3 could have three level 1 comorbid conditions (e.g. dementia, chronic pulmonary disease, and congestive heart failure), or one level 1 (e.g. dementia) and one level 2 comorbid condition (e.g. leukemia), or one level 3 condition (moderate or severe liver disease).29
Pitt bacteremia score is an acute severity of illness score. Higher scores indicate more severe illness. A patient with a score of 3 would have one level 1 marker (e.g. disoriented mental status) and one level 2 marker of acute illness (e.g. hypotension).18
Intensive care unit location on the day of first positive culture.
Time to first positive culture indicates the number of days from admission to the collection date of the index culture, with 0 indicating that the index culture was obtained on the day of admission.
For analysis purposes grouped as home/transferred from foreign country, long term acute care/hospital transfer, and long term chronic care/hospice. One person from South America had missing data for origin.
Australia, Lebanon, and Singapore.
p value comparing China, South America, and US, and distributions where applicable.