Table 1:
Comparison of acute optic neuritis from MOG antibody associated disease and multiple sclerosis
| MOGAD N=64 subjects (96 eyes) |
Multiple sclerosis N=50 subjects (51 eyes) |
p-value | |
|---|---|---|---|
| Age at onset (years), median (IQR) | 46.5 (34.3–57) | 30.4 (25.7–38.4) | <0.001 |
| Female sex, n (%) | 39 (61%) | 42 (84%) | 0.01 |
| Ethnicity, n (%) | White, 37 (58%) African American, 5 (8%) Asian, 17 (27%) Hispanic, 4 (6%) Other/unknown, 1 (2%) |
White, 27 (54%) African American, 16 (32%) Asian, 2 (4%) Hispanic, 0 (0%) Other/unknown, 5 (10%) |
<0.001 |
| Affected eye pRNFL, μm, median (IQR) | 164 (116–212) | 103 (93–113) | <0.001 |
| pRNFL thickening1,2, μm, median (IQR) | 45.5 (17–105) | 7.5 (1–18) | <0.001 |
| GCIPL thickness, μm, median (IQR) | 79 (76–83.5) | 79 (75–84) | 0.72 |
Abbreviations: MOG (myelin oligodendrocyte glycoprotein), pRNFL (peripapillary retinal nerve fiber layer), GCIPL (ganglion cell inner plexiform layer).
1
n=31 MOGAD and 48 MS eyes
2
Estimated using the contralateral unaffected eye as a surrogate for the baseline pRNFL thickness or a baseline optical coherence tomography scan prior to ON onset (if available), n=31 MOGAD and 48 MS subjects/eyes