Table 5.

Post-baseline PRO Score Trajectories

	Model Estimate	Standard Error	p-value
sPCDAI
Time (annual change in score)	−1.8	0.4	<0.001
Treatment failure (yes vs. no)	4.7	1.2	<0.001
Sex (female vs. male)	1.9	1.2	0.10
Baseline age (years)	0.2	0.2	0.31
IBD Symptoms
Time (annual change in score)	−0.4	0.3	0.14
Treatment failure (yes vs. no)	3.9	0.7	<0.001
Sex (female vs. male)	1.2	0.7	0.09
Baseline age (years)	0.2	0.1	0.18
Pain Interference
Time (annual change in score)	−1.7	0.5	<0.01
Treatment failure (yes vs. no)	5.1	1.4	<0.001
Sex (female vs. male)	1.2	1.3	0.37
Baseline age (years)	0.0	0.2	0.95
Fatigue
Time (annual change in score)	−0.9	0.6	0.11
Treatment failure (yes vs. no)	4.1	1.6	<0.01
Sex (female vs. male)	3.1	1.6	0.048
Baseline age (years)	0.3	0.3	0.25
Positive Affect
Time (annual change in score)	0.0	0.4	0.97
Treatment failure (yes vs. no)	−2.7	1.0	<0.01
Sex (female vs. male)	−1.7	0.9	0.06
Baseline age (years)	−0.3	0.2	0.07

Note. Each model controlled for baseline scores by including them as a covariate. Model estimates may be interpreted as the difference in sPCDAI score or PRO T-score associated with each of the following: an increase in time of one year; experiencing a treatment failure at any point in the study versus no treatment failure; female versus male; one year older in age at baseline. The models for sPCDAI and Fatigue included by-subject random intercepts but not random slopes because the full models with random slopes did not converge.