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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Trends Mol Med. 2022 Jan 29;28(3):237–250. doi: 10.1016/j.molmed.2022.01.002

Figure 2. Alloreactive B cell differentiation according to cytokine instructions.

Figure 2.

Fate of naive B cells dictated by IFN-g and TFH cell-derived IL-21 and according to T-bet expression: resting memory (RM) cells represent the self-renewal reservoir of B cell memory, activated memory (AM) cells are poised for differentiation into donor-specific antibody-producing plasma cells driven by IL-21, and tissue-like memory (TLM) cells in an inhibitory state driven by IFN-g signals. Plasticity between AM and TLM cell fate may exist. This figure was created with BioRender. Abbreviations: CD, cluster of differentiation; MHC, major histocompatibility complex; TCR, T cell receptor.