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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Trends Mol Med. 2022 Jan 29;28(3):237–250. doi: 10.1016/j.molmed.2022.01.002

Figure 3. Key therapeutic targets in TFH cell crosstalk with cognate B cell (key figure).

Figure 3.

The major costimulatory and cytokine receptors involved in cognate donor-antigen specific TFH-B cell interaction are depicted. Biotherapies currently evaluated in clinical trials and their specific targets are represented. This figure was created with BioRender. Abbreviations: CD, cluster of differentiation; ICOS, inducible T cell costimulator; IL, interleukin; MHC, major histocompatibility complex; TCR, T cell receptor.