Table 2.
A Detailed right hippocampal subfield volumetrics and statistics. B Detailed left hippocampal subfield volumetrics and statistics.
| CD VEH | CD NRG | WD VEH | WD NRG | |||||
|---|---|---|---|---|---|---|---|---|
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | |
| Total | 44.42 | 0.64 | 41.39 | 0.61 | 43.02 | 0.50 | 42.81 | 0.76 |
| CA1 | 14.07 | 0.18 | 13.11 | 0.24 | 13.78 | 0.27 | 13.60 | 0.30 |
| CA2 | 0.56 | 0.04 | 0.49 | 0.05 | 0.51 | 0.04 | 0.61 | 0.03 |
| CA3 | 11.83 | 0.27 | 11.06 | 0.19 | 11.46 | 0.21 | 11.30 | 0.24 |
| DG | 12.56 | 0.22 | 11.58 | 0.28 | 12.10 | 0.17 | 12.17 | 0.28 |
| SUB | 5.40 | 0.13 | 5.16 | 0.11 | 5.17 | 0.11 | 5.14 | 0.06 |
| Source of Variation | F (DFn, DFd) | P value |
|---|---|---|
| Region | F (1.647, 32.93) = 13763 | <0.0001 |
| Diet | F (1, 20) = 0.0001678 | 0.9898 |
| Drug | F (1, 20) = 6.457 | 0.0194 |
| Region x Diet | F (5, 100) = 0.1115 | 0.9896 |
| Region x Drug | F (5, 100) = 5.106 | 0.0003 |
| Diet x Drug | F (1, 20) = 4.937 | 0.0380 |
| Region x Diet x Drug | F (5, 100) = 3.751 | 0.0037 |
| Subject SS, 32.29 | ||
| CD VEH | CD NRG | WD VEH | WD NRG | |||||
|---|---|---|---|---|---|---|---|---|
| Mean | SEM | Mean | SEM | Mean | SEM | Mean | SEM | |
| Total | 46.37 | 1.09 | 43.24 | 0.92 | 44.63 | 0.27 | 44.37 | 0.72 |
| CA1 | 13.90 | 0.30 | 12.99 | 0.21 | 13.48 | 0.28 | 13.49 | 0.43 |
| CA2 | 0.88 | 0.06 | 0.76 | 0.04 | 0.84 | 0.02 | 0.83 | 0.07 |
| CA3 | 11.95 | 0.48 | 11.11 | 0.22 | 11.71 | 0.15 | 11.50 | 0.25 |
| DG | 13.44 | 0.19 | 12.38 | 0.36 | 13.12 | 0.28 | 12.70 | 0.09 |
| SUB | 6.20 | 0.18 | 5.99 | 0.18 | 6.16 | 0.20 | 5.85 | 0.14 |
| Source of variation | F (DFn, DFd) | P value |
|---|---|---|
| Region | F (1.452, 29.03) = 8810 | <0.0001 |
| Diet | F (1, 20) = 0.001380 | 0.9707 |
| Drug | F (1, 20) = 5.423 | 0.0305 |
| Region x Diet | F (5, 100) = 0.02894 | 0.9996 |
| Region x Drug | F (5, 100) = 4.558 | 0.0009 |
| Diet x Drug | F (1, 20) = 1.597 | 0.2209 |
| Region x Diet x Drug | F (5, 100) = 1.527 | 0.1882 |
| Subject SS, 60.71 | ||
Bold denotes significant effects following three-way ANOVA and post hoc comparisons between CD + VEH and CD + NRG1. Subject refers to the differences among subjects (variation source expressed as Sum of Squares, SS). Sample numbers: CD + VEH, n = 6; CD + NRG1, n = 6; WD + VEH, n = 6; WD + NRG1, n = 6. Bold denotes significant effects following three-way ANOVA and post hoc comparisons between CD + VEH and CD + NRG1. Subject refers to the differences among subjects (variation source expressed as Sum of Squares, SS). Sample numbers: CD + VEH, n = 6; CD + NRG1, n = 6; WD + VEH, n = 6; WD + NRG1, n = 6.